Naval Bajwa - An efficient 1,2-chelation-controlled reduction of protected hydroxy ketones via Red-Al

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  Publication Details (including relevant citation   information):

  Author(s):   Bajwa N, Jennings MP

 
  Source: JOURNAL OF ORGANIC

  CHEMISTRY Volume: 73 Issue: 9  Pages: 3638-3641 Published:   MAY 2 2008

 
  Times Cited: 0

  Abstract:

  In this paper, we have demonstrated that Red-Al is an efficient   chelation-controlled reducing reagent for acyclic acetal (i.e.,   MOM, MEM, SEM, and BOM) protected alpha-hydroxy ketones.   Typically, diastereomeric ratios (dr) ranged from 5 to 20:1 for   the 1,2-anti-diols in good to excellent yields.

  Address (URL): http://pubs.acs.org/doi/full/10.1021/jo800150x

 

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