Tsuyoshi Ikeda - Triterpenoids Isolated from Zizyphus jujuba Inhibit Foam Cell Formation in Macrophages.

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  Publication Details (including relevant citation   information):

  J Agric Food Chem. 2011 May   11;59(9):4544-52. Epub 2011 Apr 7.


  Because foam cell formation in macrophages is believed to play an   essential role in the progression of early atherosclerotic   lesions in vivo, prevention of foam cell formation is considered   to be one of the major targets for the treatment of   atherosclerosis. The present study examined the inhibitory effect   of 50 crude plant extracts on foam cell formation. Among those   crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS)   extracts significantly inhibited the foam cell formation induced   by acetylated LDL. Furthermore, triterpenoids such as oleanonic   acid, pomolic acid, and pomonic acid were the major active   compounds, and triterpenoids containing a carboxylic acid at C-28   play an important role in the inhibitory effect on foam cell   formation in human macrophages. These data suggest that   triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS,   may therefore be useful for the prevention of atherosclerosis.

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