Publication Details (including relevant citation information):
Volume 21, Issue 9, 1 May 2011, Pages 2616-2620
(hIcmt) is a promising anticancer target as it is important for the post-translational modification of oncogenic proteins. We herein report the synthesis and biochemical activity of 41 farnesyl- based analogs versus hIcmt. We have demonstrated that the amide linkage of a hIcmt substrate can be replaced by a sulfonamide bond to achieve hIcmt inhibition. The most potent sulfonamide-modified farnesyl analog was 6ag with an IC50 of 8.8 ± 0.5 μM for hIcmt.