Yane-Shih Wang - The De novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivatives.

Version 1

      Publication Details (including relevant citation   information):

      Wang,   Y. S.,   Russell, W. K.,Wang, Z., Y., Wan, W., Dodd, L. E., ,Pai, P. J.,   Russell, D. H. and Liu, W., The Denovo engineering of   pyrrolysyl-tRNA synthetase for genetic incorporation   ofL-phenylalanine   and its derivatives. Mol. Biosyst.  2011, 7,   714-716.


      Using evolved pyrrolysyl-tRNA   synthetase–tRNAPylCUA  pairs, L-phenylalanine,   p-iodo-L-phenylalanine and   p-bromo-L-phenylalanine have been   genetically incorporated into proteins at amber mutation sites in   E. coli.

      Address (URL): http://pubs.rsc.org/en/Content/ArticleLanding/2011/MB/c0mb00217h