Debjyoti Bandyopadhyay - Anti-Fouling Chemistry of Chiral Monolayers: Enhancing Biofilm Resistance on Racemic Surface

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  Publication Details (including relevant citation   information):

  Debjyoti Bandyopadhyay, Deepali Prashar, and Yan-Yeung Luk*

  Department of Chemistry, Syracuse University, Syracuse, New York   13244-4100, United States

  Langmuir, 2011, 27 (10), pp 6124-6131

  DOI: 10.1021/la200230t

  Publication Date (Web): April 12, 2011


  This work reports the resistance to protein adsorption and   bacterial biofilm formation by chiral monolayers of   polyol-terminated alkanethiols surrounding micrometer-sized   patterns of methyl-terminated alkanethiols on gold films. We   discover that patterned surfaces surrounded by chiral polyol   monolayers can distinguish different stages of biofilm formation.   After inoculation on the surfaces, bacteria first reversibly   attached on the chiral polyol monolayers. Over time, the bacteria   detached from the polyol surfaces, and attached on the   hydrophobic micropatterns to form biofilms. Interestingly, while   both enantiomers of gulitol- and mannonamide-terminated monolayer   resisted adsorption of proteins (bovine serum albumin, lysozyme,   and fibrinogen) and confined biofilms formed on the   micropatterns, the monolayers formed by the racemic mixture of   either pair of enantiomers exhibited stronger antifouling   chemistry against both protein adsorption and biofilm formation   than monolayers formed by one enantiomer alone. These results   reveal the different chemistries that separate the different   stages of biofilm formation, and the stereochemical influence on   resisting biofoulings at a molecular-level.

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