Ibrahim Eryazici - Cooperative Melting in Caged Dimers with Only Two DNA Duplexes

Version 1

      Publication Details (including relevant citation   information):

      Eryazici,I., Prytkova, T. R., Schatz, G.C., Nguyen, S.   T., Journal of the American Chemical Society,   2010, 132(48),17068-17070.


      Small molecule−DNA hybrids with only two parallel DNA   duplexes (rSMDH2)   displayed sharper melting profiles compared to unmodified DNA   duplexes, consistent with predictions from neighboring-duplex   theory. Using adjusted thermodynamic parameters obtained from a   coarse-grain dynamic simulation, the experimental data fit well   to an analytical model.

      Address (URL): http://pubs.acs.org/doi/abs/10.1021/ja107232x