Darby Kozak - Tunable Nano/Micropores for Particle Detection and Discrimination: Scanning Ion Occlusion Spectroscopy

Document created by Darby Kozak on Aug 22, 2014
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  Publication Details (including relevant citation   information):

  SMALL Volume: 6  Issue: 23 Pages:  2653-2658 DOI: 10.1002/smll.201001129


  Nanopore devices are extremely useful tools for the simple,

  sensitive, and high-throughput characterization of particles

  and biomolecules. However, the fixed diameter of conventional

  pores severely limits the size range of structures that

  can be effectively analyzed with a given pore. Herein we use

  a novel resizable elastic nanopore to discriminate between

  and selectively gate the passage of a mixed suspension of 100,

  220, and 400 nm particles and to detect DNA modifi cation of

  220 nm particles. Changing the pore size in real time allows

  ‘tuning’ of the signal to improve the characterization of

  closely related particle size distributions and surface-modifi ed

  particles. Tuning of the pore size to the experimental system

  at hand holds promise as an easy, robust, and versatile technique

  for the characterization of nanometer-sized materials

  and for biological sensing applications.

  Address (URL): http://