Sandeep Kumar Vashist - Interfacing carbon nanotubes with living mammalian cells and cytotoxicity issues.

Version 1

      Publication Details (including relevant citation   information):

        ACS CHEMICAL RESEARCH TOXICOLOGY,    23(7),   1131-1147, 2010

      Abstract:

      The unique structures and properties of carbon nanotubes (CNTs)   have attracted extensive investigations for many applications,   such as those in the field of biomedical materials and devices,   biosensors, drug delivery, and tissue engineering. Anticipated   large-scale productions for numerous diversified applications of   CNTs might adversely affect the environment and human health. For   successful applications in the biomedical field, the issue of   interfacing between CNTs and mammalian cells in vitro  needs to be addressed before in vivo studies can be   carried out systematically. We review the important studies   pertaining to the internalization of CNTs into the cells and the   culturing of cells on the CNT-based scaffold or support   materials. The review will focus on the description of a variety   of factors affecting CNT cytotoxicity: type of CNTs, impurities,   lengths of CNTs, aspect ratios, dispersion, chemical   modification, and assaying methods of cytotoxicity.

      Address (URL): http://pubs.acs.org/doi/abs/10.1021/tx100050h