Yingjie Zhang - Applications and modifications of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) in peptides and peptidomimetics design and discovery.

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      Publication Details (including relevant citation   information):

      Curr   Protein Pept Sci,   2010, 11 (8), 752-758.


      Tic,   short for 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, is a   kind of unnatural α-amino acids. Due to its distinct geometrical   conformation and biological activity, the structure of Tic,   regarded as the surrogate of proline and the rigid analogue of   phenylalanine or tyrosine, has been introduced into many   compounds, which target diverse enzymes or receptors. The most   successful example is that substituting the Tic residue for the   proline residue of enalapril led to an approved drug quinapril.   In this review, we will summarize the applications and   modifications of Tic in peptides and peptidomimetics design and   discovery, and hope to spark medicinal researchers’ inspiration   in the field of protein and peptide drug design and   optimization.

      Address (URL): http://www.benthamdirect.org/pages/content.php?CPPS/2010/00000011/00000008/0011K .SGM