Yingjie Zhang - Progress on Kinesin Spindle Protein Inhibitors as Anti-Cancer Agents.

Version 1

      Publication Details (including relevant citation   information):

      Anti-Cancer   Agents in Medicinal Chemistry, 2008,   8 (6), 698-704.

      Abstract:

      The   kinesin spindle protein (KSP, also known as Hs Eg5) plays an   essential part in the proper separation of spindle poles and the   correct formation of bipolar mitotic spindle during mitosis.   Inhibition of this protein results in cells apoptosis followed by   mitotic arrest and the formation of characteristic monoaster   spindles. Compared with the traditional chemotherapeutic agents   (taxanes, vinca alkaloids), KSP inhibitors (KSPi) will not lead   to the neuropathic side effects, so KSP has become a novel and an   attractive anticancer target. Accordingly, more and more interest   has been focused on the development of high effective and   selective KSPi. This review will focus on some kinds of KSPi on   the basis of introducing structure and function of KSP.

      Address (URL): http://www.benthamdirect.org/pages/content.php?ACAMC/2008/00000008/00000006/0009 W.SGM