Yingjie Zhang - The Structure and Function of Histone Deacetylases: The Target for Anti-cancer Therapy.

Version 1

      Publication Details (including relevant citation   information):

      Curr   Med Chem,   2008, 15 (27), 2840-2849.

      Abstract:

      Histone   deacetylases (HDACs) and Histone acetyltransferases (HATs) are   two kinds of enzymes, which can, by reversible deacetylation and   acetylation, modify the structure and function of chromatin   histones that are involved in the regulation of gene expression,   as well as many non-histone proteins that regulate cell function   in eukaryotes. Compared with HATs, HDACs have attracted more and   more attentions for two main reasons over the past few years.   First, the relationship of HDACs and cancer, as well as several   other diseases has been confirmed. Second, many HDAC inhibitors   (HDACi) have entered pre-clinical or clinical research as   anti-cancer agents and shown satisfying effects. HDACs, including   18 members at least, are subdivided into 4 classes that generally   have high structure similarity and related substrate specificity   within classes, but have divergent sequence and different   functions between even within classes. This review will introduce   the relationship between HDACs and cancer along with the enzymes’   structure and main function.

      Address (URL): http://www.benthamdirect.org/pages/content.php?CMC/2008/00000015/00000027/0004C. SGM