Publication Details (including relevant citation information):
Dmitry Tsvelikhovsky and Stephen L. Buchwald
J. Am. Chem. Soc., Just Accepted Manuscript
Publication Date (Web): August 12, 2011
Copyright © 2011 American Chemical Society
A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogs is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is also applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles, such as dibenzodiazepinones and dibenzooxazepinones.
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