Dmitry Tsvelikhovsky - Concise Palladium-Catalyzed Synthesis of Dibenzodiazepines and Structural Analogs

Version 1

      Publication Details (including relevant citation   information):

      Dmitry Tsvelikhovsky  and Stephen L. Buchwald

      J. Am. Chem. Soc., Just Accepted Manuscript


      DOI: 10.1021/ja206229y

      Publication Date (Web): August 12, 2011

      Copyright © 2011 American Chemical Society


      A general and highly efficient protocol for the synthesis of   dibenzodiazepines and their structural analogs is reported. In   the presence of catalytic quantities of palladium, readily   accessible precursors are cross-coupled with ammonia and then   spontaneously undergo an intramolecular condensation to form the   corresponding dibenzodiazepines in one step. This new strategy is   also applicable to the construction of a wide variety of   dibenzooxazepines and other structurally related heterocycles,   such as dibenzodiazepinones and dibenzooxazepinones.

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