Anuj Sharma - Telomerase targeted anticancer bioactive prodrug by antisense-based approach.

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      Publication Details (including relevant citation   information):

      http://www.ncbi.nlm.nih.gov/pubmed/16950563

      Abstract:

      A deoxy 11-mer oligonucleotide 5'-GTTAGGGTTAG-3', complementary   to a repeat sequence of human telomerase RNA template has been   linked through phosphate and a C-2 linker to a bioactive   tetraglycine conjugate of curcumin, a well-known antitumor herbal   spice component of turmeric. This molecule has been transfected   into KB and HeLa cell lines and found to affect cell growth in   the former. This DNA-curcumin-tetraglycine acts as a prodrug   being targeted by antisense mechanism to telomerase.

      Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/16950563