Cristina Clement - Crystallization and preliminary crystallographic characterization of three peptidic inhibitors in complex with α-thrombin.

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      Publication Details (including relevant citation   information):

      Carvalho Figueiredo A, Clement CC, Philipp M,   Barbosa Pereira PJ.

        Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan   1;67(Pt 1):54-8. Epub 2010 Dec 21.


      The serine protease thrombin plays a major role in thrombosis and   haemostasis. This has driven interest in thrombin inhibitors as   potential antithrombotic drugs. Here, the crystallization and   preliminary crystallographic analysis of human α-thrombin in   complex with three noncovalent peptide inhibitors of the general   sequence D-Phe-Pro-D-Arg-P1'-CONH2 are reported. The crystals   belonged to the orthorhombic space group P2(1)2(1)2(1) and   diffracted to beyond 1.3 Å resolution.

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