Publication Details (including relevant citation information):
Carvalho Figueiredo A, Clement CC, Philipp M, Barbosa Pereira PJ.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt 1):54-8. Epub 2010 Dec 21.
The serine protease thrombin plays a major role in thrombosis and haemostasis. This has driven interest in thrombin inhibitors as potential antithrombotic drugs. Here, the crystallization and preliminary crystallographic analysis of human α-thrombin in complex with three noncovalent peptide inhibitors of the general sequence D-Phe-Pro-D-Arg-P1'-CONH2 are reported. The crystals belonged to the orthorhombic space group P2(1)2(1)2(1) and diffracted to beyond 1.3 Å resolution.
Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/21206024