Publication Details (including relevant citation information):
| ||Wu, Z.; Hruby, V. J., Backbone Alignment Modeling of the Structure-Activity Relationships of Opioid Ligands. Journal of Chemical Information and Modeling 2011, 51, (5), 1151-1164.|
Opioid studies are an important area of modern medicinal chemistry research. In this study we have provided innovative considerations to some long-standing problems in opioid studies, specifically the opioid pharmacophore and the potential binding modes of opioid ligands. Based on a new peptide backbone-alignment concept that we have developed along with this study, we discuss a wide variety of opioid ligands with respect to their structureâ€“activity relationships.
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