Purushottamachar Puranik - Design, Synthesis and Biological Activity of Certain 3,4-Disubstituted-5-mercapto-1,2,4-triazoles and Their Hydrazino Derivatives.

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      Publication Details (including relevant citation   information):

      Bull. Korean Chem. Soc.2007, 28(12)   2235-2240.


      3-Aryloxy methyl-4-(N-pyrazin-2’yl   carboxamido)-5-mercapto-1,2,4-triazoles   (3a1-a14) were prepared starting from   potassium dithio carbazinates (2a1-a14).   These triazoles were then employed in the synthesis of 3-aryloxy   methyl-4-(N-pyrazin-2’yl carboxamido)-5-hydrazino-1,2,4-triazoles   (4a1-a14). All the newly synthesized   compounds were characterized by analytical, IR, NMR spectral   studies. The compounds were screened for their antibacterial,   antifungal, anti-inflammatory and analgesic properties. Most of   the compounds have shown significant antifungal activity while   few have shown excellent anti-inflammatory and analgesic   activity. An attempt is made to study the structure activity   relationship (SAR).

      Address (URL): http://journal.kcsnet.or.kr/main/j_search/j_archives_sub.htm?qpage=j_search&spag e=b_bkcs&dpage=ar&year=2007&vol=28&no=12