Alexander KM Leung - Anti-infoammatory and Analgesic Effects of the Ethanol Extract of Rosa multiflora Thunb. Hips

Document created by Alexander KM Leung on Aug 22, 2014
Version 1Show Document
  • View in full screen mode

  Publication Details (including relevant citation   information):

  Journal   of Ethnopharmacology, Vol.   118(2),  290-294   (2008)


  This study aimed to assess the anti-inflammatory and analgesic   effects of Fructus Rosae Multiflorae (FRM, hips of Rosa   multiflora Thunb.). FRM was extracted with 75% ethanol and   the dried extract (FRME) was administered intragastrically (i.g.)   at 100, 200 and 400 mg/kg. The anti-inflammatory effect was   evaluated in four experimental animal models and analgesic effect   in two animal models. Pretreatment with a single dose of FRME   produced significant dose-dependent anti-inflammatory effects on   carrageenin-induced rat hind paw edema, xylene-induced mouse ear   edema and acetic acid-induced mouse vascular permeation. In a   7-day study, daily administration of FRME suppressed cotton   pellet-induced rat granuloma formation. Pretreatment with a   single dose of FRME also produced dose-dependent anti-nociceptive   effects in thermally- and chemically induced mouse pain models.   In addition, a single dose of FRME at 2.4 g/kg body weight   (equivalent to 87.6 g of dried hips per kg body weight) produced   no observable acute toxicity in mice within seven days. These   results demonstrate that FRME possesses anti-inflammatory and   analgesic effects and has no obvious acute toxicity, which   advanced our understanding of the folk use of FRM in treating   various inflammatory disorders.

  Address (URL):