Alexander KM Leung - Novel Use of Silymarin as Delayed Therapy for Acetaminophen-induced Acute Hepatic Injury

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      Publication Details (including relevant citation   information):

      Research   in Complementary Medicine, Vol.   17(4), 209-213 (2010)


      Aim: Recently, we have demonstrated that silymarin has a   comparable pharmaceutical activity as Phyllanthus   urinaria extract when used to rescue mice from   acetaminophen-induced acute liver injury. In the present study,   we further compared the therapeutic action of silymarin with   N-acetyl cysteine (commonly used in clinical practice for   emergency treatments) as a rescuer in mice after administering a   lethal dose of acetaminophen for 24 h. Methods: Acute   liver injury was induced in the treatment groups by   intraperitoneally administered acetaminophen at a dose of 550   mg/kg body weight on day 1. The control group received an equal   volume of physiological saline intraperitoneally. From day 2 to   4, the treatment groups received various doses of silymarin or   N-acetyl cysteine orally once daily, while the control group and   the acetaminophen group received an equal volume of water orally.   The mortality rate was recorded in all groups. On day 5, all mice   were sacrificed for examination. Results: Silymarin   greatly improved the counteracting effects on mortality rate as   compared to N-acetyl cysteine. Conclusion: Silymarin   should be further considered as an antidote for patients with   acetaminopheninduced acute hepatic injury and delayed treatment.

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