Renatus Sinkeldam - Emissive RNA alphabet

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  Publication Details (including relevant citation   information):

  D. Shin, R. W. Sinkeldam, Y. Tor,   J. Am. Chem. Soc.    2011, 133, 14912–5


  A fluorescent ribonucleoside alphabet consisting of highly   emissive purine   (thA,   thG) and pyrimidine   (thU,   thC) analogues, all   derived from thieno[3,4-d]pyrimidine as the heterocyclic   nucleus, is described. Structural and biophysical analyses   demonstrated that the emissive analogues are faithful isomorphic   nucleoside surrogates. Photophysical analysis established that   the nucleosides offer highly desirable qualities, including   visible emission, high quantum yield, and responsiveness to   environmental perturbations, traits entirely lacking in their   native counterparts.

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