Dineshkumar Manvar - Tumor Specific Cytotoxicity and MDR-reversal Activity of Dihydropyridines

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  Publication Details (including relevant citation   information):

  InVivo, 2006, 20 (5), 637-643.


  The ability of 41 1,4-diphenyl-1,4-dihydropyridine derivatives to   inhibit the transport activity of P-glycoprotein were studied by   flow cytometry in a multidrug-resistant human colon cancer cell   line (COLO320) and in human mdr1 gene-transfected mouse lymphoma   cells (L 5178 Y). The cytotoxicities of these compounds were also   examined against human normal and cancer cell lines. The majority   of the tested compounds proved to be effective inhibitors of   rhodamine 123 outward transport, but their cytotoxicities were   not negligible. Some dihydropyridine derivatives displayed   cytotoxic activity against four human oral tumour cell lines and   against three normal human oral cell lines. There was no   clear-cut relationship between the multidrug-resistance activity   or cytotoxicity and the chemical structures of the compounds. New   ring substituents could prevent the oxidation of the ring of the   aromatic compound.

  Address (URL): http://iv.iiarjournals.org/content/20/5/637.abstract