Steven Meyers - Biocompatible and Bioactive Surface Modifications for Prolonged In Vivo Efficacy

Version 1

      Publication Details (including relevant citation   information):

      Steven R. Meyers and Mark W. Grinstaff

      Departments of Biomedical Engineering and Chemistry, Boston   University, Boston, Massachusetts 02215, United States

      Chem. Rev., Article ASAP

      DOI: 10.1021/cr2000916

      Abstract:

      Generally, medical implants, regardless of their construction   materials, will become coated in a layer of nonspecific proteins   mere seconds after implantation. This adsorbed layer activates an   irrevocable host defense mechanism, known as the foreign body   reaction, which ultimately results in the production of a fibrous   avascular capsule that isolates the device from its target   tissues, clogs the pores of membranes and sensors, and prevents   drug release from a delivery vehicle. Many devices eventually   fail because of their inability to effectively communicate with   the surrounding tissues.

      It is becoming apparent that subcellular interactions at the   biological–material interface have macroscopic outcomes. The   success of the next generation of implants depends on overcoming   limitations in biological communication by selective modification   of device surfaces. This review focuses on recent advances in   increased implant efficacy through selective surface   modifications. Several approaches coopt solutions found in the   natural world to create a surface that mimics the properties of   the cell membrane, thereby imparting a pseudobiological character   to synthetic materials. We begin with a short description of the   foreign body reaction and then examine the biocompatible and   bioactive device surface modification advances from the past five   years that hold the potential of increased in vivo effectiveness.

      Address (URL): http://pubs.acs.org/doi/full/10.1021/cr2000916