Steven Meyers - Enzymatic release of a surface-adsorbed RGD therapeutic from a cleavable peptide anchor

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      Publication Details (including relevant citation   information):

      Meyers SR, Kenan DJ, Grinstaff MW.

      Departments of Biomedical Engineering and Chemistry, Boston   University, 590 Commonwealth Ave., Boston, MA 02215, USA.

      ChemMedChem. 2008 Nov;3(11):1645-8.

      DOI: 10.1002/cmdc.200800205

      Abstract:

      Implanted medical devices inevitably promote inflammation of the   surrounding tissue. A method for enzymatically triggered   localized drug delivery would have marked benefits in dealing   with this response. Herein we present a rationally designed   peptide coating for use with medical devices such as stents, that   contains three distinct domains: 1) an implant-adsorptive   sequence, 2) an enzymatically cleavable release mechanism, and   3) a therapeutic to be delivered.

      Address (URL): http://onlinelibrary.wiley.com/doi/10.1002/cmdc.200800205/abstract