Publication Details (including relevant citation information):
Meyers SR, Kenan DJ, Grinstaff MW.
Departments of Biomedical Engineering and Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.
ChemMedChem. 2008 Nov;3(11):1645-8.
Implanted medical devices inevitably promote inflammation of the surrounding tissue. A method for enzymatically triggered localized drug delivery would have marked benefits in dealing with this response. Herein we present a rationally designed peptide coating for use with medical devices such as stents, that contains three distinct domains: 1) an implant-adsorptive sequence, 2) an enzymatically cleavable release mechanism, and 3) a therapeutic to be delivered.