Steven Meyers - Anionic amphiphilic dendrimers as antibacterial agents

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  Publication Details (including relevant citation   information):

  Meyers SR, Juhn FS, Griset AP, Luman NR, Grinstaff MW.

  Department of Biomedical Engineering, Metcalf Center for Science   and Engineering, Boston University, Boston, Massachusetts, USA.

  J Am Chem Soc. 2008 Nov 5;130(44):14444-5. Epub 2008 Oct 9.


    An anionic amphiphilic dendrimer is reported that possesses   increased cytotoxicological potency against prokaryotic cells   compared to eukaryotic cells. The half-maximal effective   concentration (EC50) for the dendrimer against Bacillus subtilis,   a Gram-positive bacterial strain, was measured to be 4.1 x 10(-5)   M, while that against human umbilical vein endothelial cells   (HUVEC) was more than 36x greater at a value of 1.5 x 10(-3) M.   EC50 ratios for two commercial amphiphiles, sodium dodecyl   sulfate (SDS) and Triton X-100, in addition to a similar   synthesized dendritic structure were at most only 3.8x greater.   Furthermore, the observed EC50 values appear to be correlated to   the critical aggregation constant (CAC) in solution suggesting a   mechanism of action for these anionic amphiphilic dendrimers   related to their supramolecular structures.

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