Publication Details (including relevant citation information):
Meyers SR, Juhn FS, Griset AP, Luman NR, Grinstaff MW.
Department of Biomedical Engineering, Metcalf Center for Science and Engineering, Boston University, Boston, Massachusetts, USA.
J Am Chem Soc. 2008 Nov 5;130(44):14444-5. Epub 2008 Oct 9.
An anionic amphiphilic dendrimer is reported that possesses increased cytotoxicological potency against prokaryotic cells compared to eukaryotic cells. The half-maximal effective concentration (EC50) for the dendrimer against Bacillus subtilis, a Gram-positive bacterial strain, was measured to be 4.1 x 10(-5) M, while that against human umbilical vein endothelial cells (HUVEC) was more than 36x greater at a value of 1.5 x 10(-3) M. EC50 ratios for two commercial amphiphiles, sodium dodecyl sulfate (SDS) and Triton X-100, in addition to a similar synthesized dendritic structure were at most only 3.8x greater. Furthermore, the observed EC50 values appear to be correlated to the critical aggregation constant (CAC) in solution suggesting a mechanism of action for these anionic amphiphilic dendrimers related to their supramolecular structures.
Address (URL): http://pubs.acs.org/doi/abs/10.1021/ja806912a