John Owen - 5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism.

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      Publication Details (including relevant citation   information):

      Cancer Res 62:6817-6819


      5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate (5-HETE) causes   PC3 cells to grow by an unknown mechanism. We find that it also   induces the cells to activate extracellular signal-regulated   kinases and Akt. Pertussis toxin inhibits both responses. 5-HETE,   5-oxo-6,8,11,14-E,Z,Z,Z-eicosatetraenoate, and   5-oxo-15-hydroxy-eicosatetraenoate are known to stimulate   leukocytes by a receptor coupled to pertussis toxin-sensitive G   proteins. Their respective relative potencies in leukocytes are   1, 10, and 3. In PC3 cells, however, these values are 10, 1, and   0. PC3 cells, we propose, express a non-leukocyte-type, G   protein-coupled, 5-HETE receptor. This novel receptor and the   extracellular signal-regulated kinase and Akt pathways it   recruits may contribute to the progression of prostate   adenocarcinoma.

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