Shuqin Yu - Preparation and physicochemical characteristics of the complex of edaravone with hydroxypropyl-β-cyclodextrin

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        The aim of this study was to prepare an inclusion complex of   edaravone, a novel free radical scavenger drug, with   hydroxypropyl-β-cyclodextrin (HP-β-CD) to improve its apparent   solubility, dissolution rate and stability. The solubility of   edaravone was evaluated by phase solubility method and the   profile displayed a typical AL-type,   indicating the formation of 1:1 stoichiometric inclusion complex.   The inclusion complex was prepared by freeze-drying method and   characterized by DTA, XRD and NMR. These results suggested that   edaravone could form inclusion complex with HP-β-CD and was   deeply included in the cavity of HP-β-CD. Additionally, the   dissolution rate and stability of the inclusion complex were   greatly improved compared with that of edaravone. These results   strongly showed that the use of HP-β-CD could be a promising   approach to improve the physicochemical characteristics of   edaravone.


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