Publication Details (including relevant citation information):
Tisdale, E. J.; Kochman, D. A.; Theodorakis, E. A. Total synthesis of atroviridin. Tetrahedron Lett. 2003, 44, 3281-3284.
A total synthesis of atroviridin based on biosynthetic principles is presented. The tetracyclic xanthone structure of the natural product was constructed by coupling an aryl bromide with an aldehyde, followed by a subsequent intramolecular conjugate addition on a quinone precursor. The aryl bromide was produced from 2,5-dimethoxybenzaldehyde via a sequence of steps involving bromination, Baeyer-Villiger oxidation, and Claisen cyclization.
Address (URL): http://dx.doi.org/10.1016/S0040-4039(03)00629-4