Eric Tisdale - Total synthesis of atroviridin.

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  Publication Details (including relevant citation   information):

  Tisdale, E. J.; Kochman, D. A.; Theodorakis, E. A. Total   synthesis of atroviridin. Tetrahedron Lett.  2003, 44, 3281-3284.

  Abstract:

  A total synthesis of atroviridin based on biosynthetic principles   is presented. The tetracyclic xanthone structure of the natural   product was constructed by coupling an aryl bromide with an   aldehyde, followed by a subsequent intramolecular conjugate   addition on a quinone precursor. The aryl bromide was produced   from 2,5-dimethoxybenzaldehyde via a sequence of steps involving   bromination, Baeyer-Villiger oxidation, and Claisen cyclization.

  Address (URL): http://dx.doi.org/10.1016/S0040-4039(03)00629-4

 

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