Ricardo Lagoa - Neuroprotective actions of flavonoids

Version 1

      Publication Details (including relevant citation   information):

      Current Medicinal   Chemistry, 18,   1195-1212, 2011

      C.   Gutierrez-Merino, C. Lopez-Sanchez, R. Lagoa, A. K. Samhan-Arias,   C. Bueno and V. Garcia-Martinez

      Abstract:

      The experimental   evidences accumulated during last years point out a relevant role   of oxidative stress in neurodegeneration. As anti-cellular   oxidative stress agents flavonoids can act either as direct   chemical antioxidants, the classic view of flavonoids as   antioxidants, or as modulators of enzymes and metabolic and   signaling pathways leading to an overshot of reactive oxygen   species (ROS) formation, a more recently emerging concept.   Flavonoids, a large family of natural antioxidants, undergo a   significant hepatic metabolism leading to flavonoid-derived   metabolites that are also bioactive as antioxidant agents. The   development of more efficient flavonoid’s based anti-oxidative   stress therapies should also take into account their   bioavailability in the brain using alternate administration   protocols, and also that the major ROS triggering the cellular   oxidative stress are not the same for all neurodegenerative   insults and diseases. On these grounds, we have reviewed the   reports on neuroprotection by different classes of flavonoids on   cellular cultures and model animals. In addition, as they are now   becoming valuable pharmacological drugs, due to their low   toxicity, the reported adverse effects of flavonoids in model   experimental animals and humans are briefly discussed.

      Address (URL): http://