Publication Details (including relevant citation information):
Acta Cryst. (1992). B48, 239-240
Endothelin, a potent regulator of vasoconstriction and hypertension, is a naturally produced peptide of 21 amino acids containing two disulfide bonds. We have crystallized endothelin from humans using the vapor-diffusion technique, characterized the crystals by X-ray diffraction analysis, and have collected the X-ray intensities to a resolution of 1.8 Angstroms. The crystals, which demonstrate physical properties similar to most protein crystals and have a comparable solvent content, are hexagonal prisms that frequently grow to lengths of 400 micrometers and widths of 150 micrometers. The space group of the crystals is P6,22 (or P6,22), with a=27.4, c=79.6 Angstroms. There is one molecule of endothelin in the asymmetric unit of crystals.
Address (URL): http://