Suntara Fueangfung - Scalable Synthetic Oligodeoxynucleotide Purification with Use of a Catching by Polymerization, Washing, and Releasing Approach

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      Publication Details (including relevant citation   information):

      Shiyue Fang* and Suntara Fueangfung  Org.Lett., 2010, 12(16), pp 3720-3723

      Abstract:

      Synthetic oligodeoxynucleotides are purified with use of a   catching by polymerization, washing, and releasing approach. The   method does not require any chromatography, and purification is   achieved by simple operations such as shaking, washing, and   extraction. It is therefore useful for large-scale purification   of synthetic oligonucleotide drugs. In addition to purification   of oligonucleotides, this catching by polymerization concept is   expected to be equally useful for purification of other synthetic   oligomers such as peptides and oligosaccharides.

      Address (URL): http://pubs.acs.org/doi/abs/10.1021/ol101316g