Publication Details (including relevant citation information):
Shiyue Fang* and Suntara Fueangfung Org.Lett., 2010, 12(16), pp 3720-3723
Synthetic oligodeoxynucleotides are purified with use of a catching by polymerization, washing, and releasing approach. The method does not require any chromatography, and purification is achieved by simple operations such as shaking, washing, and extraction. It is therefore useful for large-scale purification of synthetic oligonucleotide drugs. In addition to purification of oligonucleotides, this catching by polymerization concept is expected to be equally useful for purification of other synthetic oligomers such as peptides and oligosaccharides.
Address (URL): http://pubs.acs.org/doi/abs/10.1021/ol101316g