Abigail Weaver - A Low-Tech Analytical Method for Diethylcarbamazine Citrate in Medicated Salt

Version 1

      Publication Details (including relevant citation   information):

      Abigail Weaver, Patrick Brown, Shannon Huey, Marco Magallon, E.   Brennan Bollman, Dominique Mares,
      Thomas Streit, and Marya Lieberman

      A low-tech analytical method for diethylcarbamazine citrate   in medicated salt. PLoS Negl Trop Dis 5(2):e1005

      Abstract:

      The
      World Health Organization has called for an effort to eliminate   Lymphatic
      Filariasis (LF) around the world. In regions where the disease is   endemic, local
      production and distribution of medicated salt dosed with   diethylcarbamazine
      (DEC) has been an effective method for eradicating LF. A partner   of the Notre
      Dame Haiti program, Group SPES in Port-au-Prince, Haiti, produces   a medicated
      salt called Bon Sel. Coarse salt is pre-washed and sprayed with a   solution of
      DEC citrate and potassium iodate. Iodine levels are routinely   monitored on site
      by a titrimetric method. However, the factory had no method for   monitoring DEC.
      Critical analytical issues include 1) determining whether the   amount of DEC in
      each lot of Bon Sel is within safe and therapeutically useful   limits, 2)
      monitoring variability within and between production runs, and 3)   determining
      the effect of a common local practice (washing salt before use)   on the
      availability of DEC. This paper describes a novel titrimetric   method for
      analysis of DEC citrate in medicated salt. The analysis needs no   electrical
      power and requires only a balance, volumetric glassware, and   burets that most
      salt production programs have on hand for monitoring iodine   levels. The staff of
      the factory used this analysis method on site to detect   underloading of DEC on
      the salt by their sprayer and to test a process change that fixed   the
      problem.

      Address (URL): http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001005