Purushottamachar Puranik - A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.

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  Publication Details (including relevant citation   information):

  J Med Chem. 2005 Jul   28;48(15):5047-51.


  We have developed a procedure for the synthesis of   N-hydroxy-N(1)-phenyloctanediamide (suberoylanilide hydroxamic   acid (SAHA)), providing the product in 79.8% yield. SAHA is a   potent inhibitor of histone deacetylase, induces differentiation   and/or apoptosis in certain transformed cells in culture, and   suppressed the growth of human prostate cancer LNCaP and PC-3   cell lines. The combination of SAHA with other compounds   inhibited cell proliferation of LNCaP cells in additive fashion   and resulted in synergistic growth inhibition.

  Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/16033284