Danilo Giribone - Synthesis of the Taxane Analogue PNU-105298 labeled with Carbon-14 and with Deuterium

Version 1

      Publication Details (including relevant citation   information):

      D.Giribone and E.Fontana

      Journal of Labelled Compounds and Radiopharmaceuticals,   (2000) 43:933-41


      In this paper the preparations of the taxane analogue PNU-105298   (1), labelled with deuterium and with carbon-14   are described. A three-step sequence starting from the   commercially available   (tert-[2H9]butyl)amine afforded   the deuterium specifically labelled final compound   [2H9]PNU-105298 (1a). The   preparation of the carbon-14 labelled final compound   [14C]PNU-105298 (1b) was carried out   in a similar fashion yielding the radiochemically pure product   with a specific activity of 2·15 GBq/mmol

      Address (URL): http://onlinelibrary.wiley.com/doi/10.1002/1099-1344(200008)43:9%3C933::AID-JLCR 381%3E3.0.CO;2-K/abstract