Ivan Kempson - Complete microscale profiling of tumor microangiogenesis: A microradiological methodology reveals fundamental aspects of tumor angiogenesis and yields an array of quantitative parameters for its characterization

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  Publication Details (including relevant citation   information):

  CC Chien, IM Kempson,   et al, Complete microscale   profiling of tumor microangiogenesis: A microradiological   methodology reveals fundamental aspects of tumor angiogenesis and   yields an array of quantitative parameters for its   characterization, Biotechnology Advances, In press.  doi:10.1016/j.biotechadv.2011.12.001

  Abstract:

  Complete profiling would substantially facilitate the fundamental   understanding of tumor angiogenesis and of possible   anti-angiogenesis cancer treatments. We developed an integrated   synchrotron-based methodology with excellent performances:   detection of very small vessels by high spatial resolution (~ 1   μm) and nanoparticle contrast enhancement, in vivo dynamics   investigations with high temporal resolution (~ 1 ms), and   three-dimensional quantitative morphology parametrization by   computer tracing. The smallest (3-10 μm) microvessels were found   to constitute > 80% of the tumor vasculature and exhibit many   structural anomalies. Practical applications are presented,   including vessel microanalysis in xenografted tumors, monitoring   the effects of anti-angiogenetic agents and in vivo detection of   tumor vascular rheological properties.

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