Ivan Kempson - X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors

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      Publication Details (including relevant citation   information):

      Wang CH, Liu   CJ, Chien CC, Chen HT, Hua TE, Leng WH, Chen HH, Kempson IM, Hwu   Y, Hsiao M, Lai TC, Wang JL, Yang CS, Lin HM, Chen YJ,   Margaritondo G, X-ray synthesized PEGylated (polyethylene glycol   coated) gold nanoparticles in mice strongly accumulate in tumors,   Materials Chemistry and Physics, 126,352–356,   2011


      The spatial distribution of X-ray synthesized, PEG coated Au   nanoparticles in cancer-bearing mice and their time dependent   accumulation were investigated with inductive coupled plasma –   optical emission spectroscopy (ICP-OES), transmission electron   microscopy (TEM) and histological imaging. The results   conclusively demonstrate that the particles strongly accumulate   in tumor regions; up to ∼25 times more than in normal muscle   tissue. This accumulation increases with the time after injection   for up to ∼12 h in tumor, spleen and liver tissues, whereas for   most non-tumor regions it saturates or decreases (blood, lung,   brain, heart, and kidney). The impact of this result is discussed   with special emphasis on passive targeted drug delivery and could   also be used for the delineation and early-stage imaging of small   tumors.

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