Publication Details (including relevant citation information):
Wang CH, Liu CJ, Chien CC, Chen HT, Hua TE, Leng WH, Chen HH, Kempson IM, Hwu Y, Hsiao M, Lai TC, Wang JL, Yang CS, Lin HM, Chen YJ, Margaritondo G, X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors, Materials Chemistry and Physics, 126,352–356, 2011
The spatial distribution of X-ray synthesized, PEG coated Au nanoparticles in cancer-bearing mice and their time dependent accumulation were investigated with inductive coupled plasma – optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM) and histological imaging. The results conclusively demonstrate that the particles strongly accumulate in tumor regions; up to ∼25 times more than in normal muscle tissue. This accumulation increases with the time after injection for up to ∼12 h in tumor, spleen and liver tissues, whereas for most non-tumor regions it saturates or decreases (blood, lung, brain, heart, and kidney). The impact of this result is discussed with special emphasis on passive targeted drug delivery and could also be used for the delineation and early-stage imaging of small tumors.
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