Ivan Kempson - Enhancement of Cell Radiation Sensitivity by Pegylated Gold Nanoparticles

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  Publication Details (including relevant citation   information):

  CJ Liu, CH   Wang, TE Hua, WH Leng, CC Chien, ST Chen, HH Chen, CL Wang, IM   Kempson, Y Hwu, TC Lai, HS Hsiao, CS Yang, YJ Chen, G   Margaritondo, Enhancement of Cell Radiation Sensitivity by   Pegylated Gold Nanoparticles. Physics in Medicine and   Biology, 55,931-945, 2010.

  Abstract:

  Biocompatible Au nanoparticles with surfaces modified by PEG   (polyethylene glycol) were developed in view of possible   applications for the enhancement of radiotherapy. Such   nanoparticles exhibit preferential deposition at tumor sites due   to the enhanced permeation and retention (EPR) effect. Here, we   systematically studied their effects on EMT-6 and CT26 cell   survival rates during irradiation for a dose up to 10Gywith a   commercial biological irradiator (Eaverage = 73 keV), a Cu-Kα1   x-ray source (8.048 keV), a monochromatized synchrotron source   (6.5 keV), a radio-oncology linear accelerator (6 MeV) and a   proton source (3 MeV). The percentage of surviving cells after   irradiation was found to decrease by ∼2–45% in the presence of   PEG-Au nanoparticles ([Au] = 400, 500 or 1000 μM). The cell   survival rates decreased as a function of the dose for all   sources and nanoparticle concentrations. These results could open   the way to more effective cancer irradiation therapies by using   nanoparticles with optimized surface treatment. Difficulties in   applying MTT assays were also brought to light, showing that this   approach is not suitable for radiobiology.

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