Publication Details (including relevant citation information):
L. Wang, J. Luo, S. Shan, E. Crew, J. Yin, Wallek, S. Wong, C.J. Zhong, “Bacterial inactivation using silver-coated magnetic nanoparticles as functional antimicrobial agents”, Anal. Chem., 2011, 83, 8688–8695.
The ability for silver nanoparticles to function as
an antibacterial agent while being separable from the target
fluids is important for bacterial inactivation in biological fluids.
This report describes the analysis of the antimicrobial activities
of silver-coated magnetic nanoparticles synthesized by wet
chemical methods. The bacterial inactivation of several types
of bacteria was analyzed, including Gram-positive bacteria
(Staphylococcus aureus and Bacillus cereus) and Gram-negative
bacteria (Pseudomonas aeruginosa, Enterobacter cloacae, and
Escherichia coli). The results have demonstrated the viability
of the silver-coated magnetic nanoparticles for achieving effective bacterial inactivation efficiency comparable to and better than that
of silver nanoparticles conventionally used. The bacteria inactivation efficiency of our silver-coated MnZn ferrite (MZF@Ag)
nanoparticles was also determined for blood platelets samples, demonstrating the potential of utilization in inactivating bacterial
growth in platelets prior to transfusion to ensure blood product safety, which also has important implications for enabling the
capability of effective separation, delivery, and targeting of the antibacterial agents.
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