Elizabeth Crew - Bacterial inactivation using silver-coated magnetic nanoparticles as functional antimicrobial agents

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      Publication Details (including relevant citation   information):

      L. Wang, J. Luo,   S. Shan, E.   Crew, J. Yin, Wallek, S. Wong, C.J. Zhong, “Bacterial   inactivation using silver-coated magnetic nanoparticles as   functional antimicrobial agents”, Anal. Chem.,   2011, 83, 8688–8695.


      The ability for silver nanoparticles to function as

      an antibacterial agent while being separable from the target

      fluids is important for bacterial inactivation in biological   fluids.

      This report describes the analysis of the antimicrobial   activities

      of silver-coated magnetic nanoparticles synthesized by wet

      chemical methods. The bacterial inactivation of several types

      of bacteria was analyzed, including Gram-positive bacteria

      (Staphylococcus aureus and Bacillus cereus) and Gram-negative

      bacteria (Pseudomonas aeruginosa, Enterobacter cloacae, and

      Escherichia coli). The results have demonstrated the viability

      of the silver-coated magnetic nanoparticles for achieving   effective bacterial inactivation efficiency comparable to and   better than that

      of silver nanoparticles conventionally used. The bacteria   inactivation efficiency of our silver-coated MnZn ferrite   (MZF@Ag)

      nanoparticles was also determined for blood platelets samples,   demonstrating the potential of utilization in inactivating   bacterial

      growth in platelets prior to transfusion to ensure blood product   safety, which also has important implications for enabling the

      capability of effective separation, delivery, and targeting of   the antibacterial agents.

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