Elizabeth Crew - Nanoparticle-Structured Thin Film Sensor Arrays for Breath Sensing

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      Publication Details (including relevant citation   information):

      J. Luo, J. Luo, L.   Wang, X. Shi, J. Yin, E. Crew, S. Lu, L. M. Lesperance,  C.J. Zhong, Sensors &   Actuators, B, 2012, 161, 845–854.


      Chemiresistor sensor arrays with nanoparticle-structured thin   films and coupled with pattern recognition engine could enable   chemical sensing of biomarker molecules such as acetone in human   breath samples with high sensitivity and selectivity, which   serves as an intriguing approach to developing potential medical   device for noninvasive monitoring of diabetes. This report   describes the results of a proof-of-concept investigation to   demonstrate the viability of such sensor arrays with the   nanostructured sensing films for the detection of human breath   and acetone vapor (a volatile biomarker in diabetics’ breath).   The nanostructured sensing films were prepared by self-assembly   of monolayer-capped gold nanoparticles on an array of   chemiresistors using functionalized alkyl thiols as linking   molecules. In addition to showing the viability for quantitative   detection of acetone, the investigation focused on the   understanding of how differences in human breaths could impact   the sensor array recognition characteristics. The results

      have revealed that the difference in data scattering between male   and female’s breath samples was relatively small. The data   distribution between breath samples obtained under controlled   fasting and food conditions depends on the design parameters of   the sensor arrays. The results have demonstrated the potential of   the sensor arrays coupled with pattern recognition for the   detection of acetone in diabetic breath, which upon further   refinements and testing could lead to a useful portable sensor   device for human breath recognition.

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