Brad Sleebs - Development of substituted 7-pheny-4-aminobenzothieno[3,2-d]pyrimidines as potent LIMK1 inhibitors

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      Publication Details (including relevant citation   information):

      Medicinal   Chemistry Communications (2011),   2,   982-986.


      7-Phenyl-4-aminobenzothieno[3,2-d]pyrimidines were   previously reported to exhibit moderate LIMK1 inhibition. Further   exploration of SAR around the 7-phenyl moiety has led to the   development of a lead series with an increased potency for LIMK1.   Evaluation of physicochemical and ADME properties, and off-target   kinase screens has seen this novel series emerge as a promising   platform for a set of tool compounds for evaluating LIMK as a   therapeutic target.

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