Brad Sleebs - Identification of substituted Gewald adducts as LIMK1 inhibitors

Document created by Brad Sleebs on Aug 22, 2014
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  Publication Details (including relevant citation   information):

  Bioorganic   and Medicinal Chemistry Letters (2011),   21(19),   5992-5994.


  4-Aminobenzothieno[3,2-d]pyrimidines were previously   identified in a high throughput screening campaign as LIMK1   inhibitors. Scaffold reversal led to the identification of a   series of simple 5,6-substituted   4-aminothieno[2,3-d]pyrimidines with low micromolar   inhibition of LIMK1.

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