Brad Sleebs - Identification of substituted Gewald adducts as LIMK1 inhibitors

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      Publication Details (including relevant citation   information):

      Bioorganic   and Medicinal Chemistry Letters (2011),   21(19),   5992-5994.

      Abstract:

      4-Aminobenzothieno[3,2-d]pyrimidines were previously   identified in a high throughput screening campaign as LIMK1   inhibitors. Scaffold reversal led to the identification of a   series of simple 5,6-substituted   4-aminothieno[2,3-d]pyrimidines with low micromolar   inhibition of LIMK1.

      Address (URL): http://dx.doi.org.ezp.lib.unimelb.edu.au/10.1016/j.bmcl.2011.07.050