Publication Details (including relevant citation information):
E Smith, D Gancarz, A Rofe, IM Kempson, J Weber, AL Juhasz, Antagonistic effects of cadmium on lead accumulation in pregnant and non-pregnant mice, Journal of Hazardous Materials, 199-200, 453-456, 2012.
People are frequently exposed to combinations of contaminants but there is a paucity of data on the effects of mixed contaminants at low doses. This study investigated the influence of cadmium (Cd) on lead (Pb) accumulation in pregnant and non-pregnant mice following exposure to contaminated soil.
Exposure to Pb from contaminated soils increased Pb accumulation in both pregnant and non-pregnant mice compared to unexposed control animals (pregnant and non-pregnant). Lead accumulation in the liver and kidneys of exposure pregnant mice (40±15 mg Pb kg−1) was significantly higher (P < 0.05) than concentrations detected in control pregnant mice (<1 mg Pb kg−1). The presence of Cd in contaminated soil had a major effect on the Pb and Fe accumulation in the kidneys and liver, respectively. This study shows that Pb uptake is mediated by the presence of Cd in the co-contaminated soil and demonstrates that further research is required to investigate the influence of co-contaminants on human exposure at sub-chronic concentrations.
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