Publication Details (including relevant citation information):
Australian Journal of Chemistry (2005), 58(11), 778-784.
N-Methyl β-amino acids are potentially useful amino acid derivatives for incorporation in lead peptide therapeutics. The syntheses of five such compounds are presented. Their synthesis via 6-oxazinanones was low yielding. Alternatively, reductive cleavage of a 5-oxazolidinone gave the N-methyl α-amino acid, which was then homologated via an Arndt–Eistert procedure in high yield to give the N-methyl β-amino acid.
Address (URL): http://dx.doi.org/10.1071/CH05199