Ivan Kempson - Fate of Intravenously Administered Gold Nanoparticles in Hair Follicles: Follicular Delivery, Pharmacokinetic Interpretation, and Excretion

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      Publication Details (including relevant citation   information):

      I.M. Kempson et al., Adv. Healthcare Mater. 2012, DOI:   10.1002/adhm.201200101

      Abstract:

      Gold nanoparticles (GNPs) are intravenously administered to mice.   Deposition at the pilosebacious unit and whiskers is visualized   with X-ray fluorescence after 30 minutes and 14 days. After 30   minutes the dermal papilla, bulge region, and root sheath all   contain NPs. GNPs are driven externally out from follicles,   counteractive to transfollicular delivery. After 14 days, gold   bands in hairs reflect pharmacokinetic profiles indicating blood   concentration kinetics. Elimination rate constants infer   half-lives from 3 hairs from an individual mouse within   reasonable agreement (6.08, 7.15, and 8.66 hours). 3D   reconstruction of NP distributions with confocal microscopy   identifies aggregates within the medullary canal. Intermittent NP   deposition continues randomly over the two week period   demonstrating prolonged NP mobility in vivo. NPs are still   retained at the hair bulb after 14 days. The observations further   account for the excretory mechanisms of NPs and their behavior in   the pilosebacous unit, and demonstrate monitoring pharmacokinetic   behavior in individual animals.

      Address (URL): http://onlinelibrary.wiley.com/doi/10.1002/adhm.201200101/abstract