Ivan Kempson - Hair analysis as a biomonitor for toxicology, disease and health status

Version 1

      Publication Details (including relevant citation   information):

      IM Kempson, E   Lombi, Hair analysis as a biomonitor for toxicology, disease and   health status, Chemical Society Reviews,   40,3915-3940, 2011.

      Abstract:

      Hair analysis receives a large amount of academic and commercial   interest for wide-ranging applications. However, in many   instances, especially for elemental or ‘mineral’ analysis, the   degree of success of analytical interpretation has been quite   minimal with respect to the extent of such

      endeavors. In this critical review we address the questions   surrounding hair analysis with specific intent of discovering   what hair concentrations can actually relate to in a biogenic   sense. This is done from a chemistry perspective to explain why   and how elements are incorporated into hair and their meaning.   This includes an overview of variables attributed to altering   hair concentrations, such as age, gender, melanin content, and   other less reported factors. Hair elemental concentrations are   reviewed with regard to morbidity, with specific examples of   disease related effects summarized. The application of hair   analysis for epidemiology and etiology studies is enforced. A   section is dedicated specifically to the area of population   studies with regards to mercury, which highlights how endogenous   and exogenous incorporation relies on species dependant   metabolism and metabolic products. Many of the considerations are   relevant to other areas of interest in hair analysis, such as for   drug and isotopic analysis. Inclusion of a table of elemental   concentrations in hair should act as a valuable reference (298   references).

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