Raviraj Vankayala - Biocompatibility of polymer grafted core/shell iron/carbon nanoparticles

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      Publication Details (including relevant citation   information): Mu, Qingxin, Yang, Lei, Davis, James C.,   Vankayala, Raviraj, Hwang, Kuo Chu, Zhao, Jincai, Yan, Bing,   Biomaterials, 2010, 31 (19),   pp 5083-5090

      Abstract: For biomedical applications, emerging   nanostructures requires stringent evaluations for their   biocompatibility. Core/shell iron/carbon nanoparticles (Fe@CNPs)   are nanomaterials that have potential applications in magnetic   resonance imaging (MRI), magnetic hyperthermia and drug delivery.   However, their interactions with biological systems are totally   unknown. To evaluate their potential cellular perturbations and   explore the relationships between their biocompatibility and   surface chemistry, we synthesized polymer grafted Fe@CNPs with   diverse chemistry modifications on surface and investigated their   dynamic cellular responses, cell uptake, oxidative stress and   their effects on cell apoptosis and cell cycle. The results show   that biocompatibility of Fe@CNPs is both surface chemistry   dependent and cell type specific. Except for the carboxyl   modified Fe@CNPs, all other Fe@CNPs present low toxicity and can   be used for further functionalization and in a wide range of   biomedical applications.

      Address (URL): http://www.sciencedirect.com/science/article/pii/S0142961210003765