Ann Kimble Hill - A review of factors affecting the success of membrane protein crystallization using bicelles

Document created by Ann Kimble Hill on Aug 22, 2014
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  Publication Details (including relevant citation   information): Kimble-Hill, Ann, pp 1-12

  Abstract: Several reports have been published   detailing various platforms for obtaining crystals of membrane   proteins to determine their structure including those that use   disk shaped bilayers called bicelles. While these crystals have   been readily grown and used for X-ray diffraction, the general   understanding as to why bicelles are adequate for such a   procedure or how to rationally choose conditions remains unknown.   This review intends to discuss issues of protein stabilization   and precipitation in the presence of lipids that may influence   crystal formation.

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