Publication Details (including relevant citation information):
Tianqing Liu, Aidan Cousins, Chia-Chi Chien, Ivan Kempson, Sarah Thompson, Yeukuang Hwu, Benjamin Thierry, Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node, Cancer Letters, 2012, dx.doi.org/10.1016/j.canlet.2012.09.024
This study was designed to demonstrate the potential of small nanoparticulate lymphotropic contrast agents designed to bind with high affinity to lymphoid cells over expressing the CD45 antigen. To this end, small gold nanoparticles used as model were conjugated to anti-CD45 antibodies and injected in mice in the dorsal toe of the fore/hind paw. Chemical analysis demonstrated rapid uptake and transport of the nanoparticles in the lymphatic as well as significant retention of the nanoparticles with high binding affinity to lymphoid cells in the popliteal and axillary lymph nodes in comparison to non-targeted nanoparticles.
Address (URL): http://dx.doi.org/10.1016/j.canlet.2012.09.024