Ivan Kempson - Immunospecific targeting of CD45 expressing lymphoid cells: Towards improved detection agents of the sentinel lymph node

Version 1

      Publication Details (including relevant citation   information):

      Tianqing Liu, Aidan Cousins, Chia-Chi Chien, Ivan Kempson, Sarah   Thompson, Yeukuang Hwu, Benjamin Thierry, Immunospecific   targeting of CD45 expressing lymphoid cells: Towards improved   detection agents of the sentinel lymph node, Cancer Letters,   2012, dx.doi.org/10.1016/j.canlet.2012.09.024

      Abstract:

      This study was designed to demonstrate the potential of small   nanoparticulate lymphotropic contrast agents designed to bind   with high affinity to lymphoid cells over expressing the CD45   antigen. To this end, small gold nanoparticles used as model were   conjugated to anti-CD45 antibodies and injected in mice in the   dorsal toe of the fore/hind paw. Chemical analysis demonstrated   rapid uptake and transport of the nanoparticles in the lymphatic   as well as significant retention of the nanoparticles with high   binding affinity to lymphoid cells in the popliteal and axillary   lymph nodes in comparison to non-targeted nanoparticles.

      Address (URL): http://dx.doi.org/10.1016/j.canlet.2012.09.024