Katarzyna Grubel - New Iron–Sulfur Clusters Help Hydrogenases Tolerate Oxygen

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  Publication Details (including relevant citation   information):

  Katarzyna Grubel, Patrick L. Holland Angewandte Chemie   International Edition, 2012, 51, 3308-3310;   DOI: 10.1002/anie.201108761


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  One S less: Recent crystallographic studies have   revealed a new, oxygen-tolerant kind of iron–sulfide cluster   [4Fe-3S], which contains only three rather than four sulfur atoms   in its cage (see picture; yellow=S, red=Fe, blue=N,   green=cysteine). It is proposed that the cluster's ability to   transfer multiple electrons increases the oxygen tolerance by   enabling the enzyme to reduce O2 rapidly, converting   the dioxygen into harmless water before it can damage the   protein.

  Address (URL): http://onlinelibrary.wiley.com/doi/10.1002/anie.201108761/abstract