Ann Newman - Characterizing Miscibility in Amorphous Solid Dispersions

Document created by Ann Newman on Aug 22, 2014
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  Publication Details (including relevant citation   information):

  A. Newan, E. Munson. Amer. Pharm.   Rev.2012, April, 92-98


  Amorphous solid dispersions are being used more frequently in the   pharmaceutical industry to address bioavailability   problems with poorly soluble drugs. Since amorphous dispersions   are inherently metastable, there is always a possibility that the   drug will convert to the more stable crystalline form, resulting   in decreased bioavailability. One way to increase confidence that   the material will not recrystallize is to ensure that the drug   and polymer are miscible. In this article some important methods   used to characterize drug-polymer miscibility are described and   evaluated.

  Address (URL): ing-Miscibility-in-Amorphous-Solid-Dispersions/