Devandran Krishnan - Lipase catalysed Amino sugar derivative in Tri-solvent mixture

Document created by Devandran Krishnan on Aug 22, 2014
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  In this work, a new type of amino sugar derivative tagged as   amino sugar similar to N-acetyl-glucosamine, commonly used in   medical

  field as medicine to treat osteoarthritis has been synthesized.   This amino sugar derivative produced from glucose and propylamine   with

  the aid of immobilized Candida antarctica (Novozyme 435) lipase,   as catalyst. Mixtures of solvent influence the high solubility of   sugar

  and thus increasing the yield. Optimization studies such as time,   molar ratio, temperature and enzyme quantity conducted for   optimization.

  Optimized condition yields 73.37 % amino sugar was obtained upon   2 h of reaction, 1:5 molar ratio of substrates, 40 ºC temperature

  and 17 % enzyme mass

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