Daichi Nakamura - Diarylprolinol in an Asymmetric, Direct Cross-Aldol Reaction with Alkynyl Aldehydes

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      Publication Details (including relevant citation   information): Hayashi, Yujiro, Kojima, Masahiro, Yasui,   Yusuke, Kanda, Yuta, Mukaiyama, Takasuke, Shomura, Hiroki,   Nakamura, Daichi, Ritmaleni, Sato, Itaru, ChemCatChem,   2013, 5 (10), pp 2887-2892

      Abstract: The direct cross-aldol reaction of   alkynyl aldehydes catalyzed by a trifluoromethylated   diarylprolinol provides a practical route for the highly   enantioselective synthesis of chiral β-alkynyl-β-hydroxy   aldehydes. Good anti selectivity and excellent enantioselectivity   were obtained in the reactions of silylpropynals, which afford   synthetically useful chiral building blocks.

      Address (URL): http://dx.doi.org/10.1002/cctc.201300390